Glutamatergic transmission in schizophrenia
نویسندگان
چکیده
منابع مشابه
Glutamatergic theories of schizophrenia.
Schizophrenia is a serious mental disorder that affects up to 1% of the population worldwide. Traditional models of schizophrenia have emphasized dopaminergic dysfunction. Over the last 20 years, however, limitations of the dopamine model have become increasingly apparent, necessitating development of alternative models. Glutamatergic models are based upon the observation that the psychotomimet...
متن کامل[Glutamatergic hypothesis of schizophrenia].
Schizophrenia is a devastating psychiatric disorder whose pathophysiology has not been fully clarified yet. Although dopamine dysfunction in schizophrenia is unequivocal, there are many evidences suggesting the involvement of the glutamatergic system. This paper briefly describes some basic knowledge regarding the functioning of the glutamatergic receptors with emphasis on the N-methyl-D-aspart...
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It is accepted that both positive and negative symptoms of schizophrenia may be due to hypofunction of glutamatergic pathways leading to altered dopaminergic neurotransmission activity. Specifically, there may be diminished glutamatergic signaling at the level of the NMDA receptors, but direct receptor agonists have no clinical utility due to their nonspecific actions and undesirable side effec...
متن کاملNeurochemistry of Schizophrenia: Glutamatergic Abnormalities
Multiple neurotransmitters have been implicated in schizophrenia. Dopamine is the neurotransmitter most often hypothesized to be associated with the pathophysiology of schizophrenia for two reasons. First, dopaminergic agonists can cause or exacerbate psychotic symptoms. Second, the correlation between antipsychotic efficacy and D2 dopamine-receptor blockade is excellent. For these reasons, a n...
متن کاملModulation of Basal Glutamatergic Transmission by Nicotinic Acetylcholine Receptors in Rat Hippocampal Slices
Objective(s) Nicotinic acetylcholine receptors (nAChRs) regulate epileptiform activity and produce a sustained pro-epileptogenic action within the hippocampal slices. In the present study, we investigated the effect of nAChRs on evoked glutamatergic synaptic transmission in area CA3 and CA1 of rat hippocampal slices to identify possible excitatory circuits through which activation of nAChRs pr...
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ژورنال
عنوان ژورنال: Current Opinion in Psychiatry
سال: 2012
ISSN: 0951-7367
DOI: 10.1097/yco.0b013e32835035b2